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One of the preventive modalities is thought to be vitamin D (1, 25-dihydroxy vitamin D3) supplementation as evidenced by some observational studies. To date, there is no proven curative treatment for this virus as a result, prevention remains to be the best strategy to combat COVID-19 pandemic. Till the 20th of December 2020, around 75 million COVID-19 cases and 1.7 million deaths were reported worldwide ( 7). World Health Organization (WHO) declared the COVID-19 outbreak to be a public health emergency on Janu( 5) and a pandemic on Ma( 6). Coronavirus disease was first reported at Wuhan City, China in December 2020 ( 3, 4).
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Severe Acute Respiratory Syndrome Coronavirus 2 is one of the coronavirus families, a family that was responsible for Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS) ( 2). The limited currently available data suggest that sufficient Vitamin D level in serum is associated with a significantly decreased risk of COVID-19 infection.Ĭoronavirus disease (COVID-19) is a respiratory and systemic disorder caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) or novel Coronavirus (nCoV) ( 1). The subgroup analysis revealed that the risk of acquiring COVID-19 infection was relatively higher in the case-control study design (OR = 1.81).Ĭonclusions: In conclusion, low serum 25 (OH) Vitamin-D level was significantly associated with a higher risk of COVID-19 infection. Begg's test also revealed that there was no significant publication bias between the studies ( P = 0.764). The pooled analysis showed that individuals with Vitamin-D deficiency were 80% more likely to acquire COVID-19 infection as compared to those who have sufficient Vitamin D levels (OR = 1.80 95%CI: 1.72, 1.88). The qualitative synthesis indicated that vitamin D deficient individuals were at higher risk of COVID-19 infection as compared to vitamin D sufficient patients. Results: The electronic and supplementary searches for this review yielded 318 records from which, only 14 of them met the inclusion criteria. This systematic review and meta-analysis are reported according to the preferred reporting items for systematic review and meta-analysis (PRISMA) guideline. Meta-analysis with a random-effects model was conducted and odds ratio with their 95%CI were reported. The qualities of the included studies were evaluated using the JBI tools. Studies that assessed the effect of vitamin D level on COVID-19/SARS-2 infection were considered for the review. Methods: A systematic literature search of databases (PUBMED/MEDLINE, Cochrane/Wiley library, Scopus, and SciELO) were conducted from May 15, 2020, to December 20, 2020. Therefore, the present review aimed to summarize the available evidence regarding the association between Vitamin D levels and the risk of COVID-19 infection. However, there is no conclusive evidence on its impact on COVID-19 infection. Vitamin D deficiency (VDD) has been proposed to play a role in coronavirus infection (COVID-19). To date, there is no proven curative treatment for this virus as a result, prevention remains to be the best strategy to combat coronavirus infection (COVID-19). doi: 10.1126/: Coronavirus disease (COVID-19) is a respiratory and systemic disorder caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) or novel Coronavirus (nCoV). Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, Ochoa MT, Schauber J, Wu K, Meinken C, et al. Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Grant WB, Lahore H, McDonnell SL, Baggerly CA, French CB, Aliano JL, et al. Association of vitamin D supplementation with respiratory tract infection in infants. Hong M, Xiong T, Huang J, Wu Y, Lin L, Zhang Z, Huang L, Gao D, Wang H, Kang C, Gao Q, Yang X, Yang N, Hao L. The interplay between vitamin D and viral infections. Teymoori-Rad M, Shokri F, Salimi V, Marashi SM.
Vitamin d video serial key update#
The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status. Guo YR, Cao QD, Hong ZS, Tan YY, Chen SD, Jin HJ, Tan KS, Wang DY, Yan Y.